The main focuses of our group is single cell systems biology.  We use super-resolution, sequential barcoded FISH, live cell microscopy to study gene regulatory networks in cells and organisms. 

We demonstrated a technique that can multiplex detection of 200 mRNAs in single cells from brain tissues using sequential rehyb FISH barcoding [link]. We are working on expanding the throughput of the technique and applying it to multi-cellular organisms to study developmental processes.

News & Events

Our paper about MEMOIR is highligted on Caltech news!
"The Allen Discovery Center for Cell Lineage Tracing"

Our new paper published on Biophysical Journal!
"Multiplexed Dynamic Imaging of Genomic Loci by Combined CRISPR Imaging and DNA Sequential FISH"

Our recent paper about MEMOIR is highlighted by Nature News! "Systems biology: Molecular memoirs of a cellular family"

Our new Nature paper published!
"Synthetic recording and in situ readout of lineage information in single cells"

Demonstration of 200 mRNAs multiplexing in brain tissues!
"In Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse Hippocampus"

Caltech    last update: 07/13/2017